University of Florida, Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS)
Professor and Scientist
Throughout my career, I have pushed cutting-edge magnetic resonance (MR) technology in order to answer clinically relevant physiology and metabolomics questions. Diverse collaborations with investigators with different backgrounds (physiologist, cell biologist, engineers, biochemist, physicists, clinicians, etc) have helped me to successfully tackle common problems. My primary area of focus had been the development of translational noninvasive imaging and spectroscopy techniques for clinical applications, with extensive experiences in both animal models and patients. I had the good fortune of performing my Ph.D. work focused on in vivo metabolism using MR under the guidance of the late Drs. Jack Leigh, Britton Chance, and Mildred Cohn at the University of Pennsylvania. With this basic training in biophysics and metabolism, my post-doctoral fellowship was performed with Dr. H. Lee Sweeney in the Department of Physiology at the University of Pennsylvania.
During my time as a post-doctoral fellow, I expanded my knowledge of MR to study the in vivo physiology and metabolism of dystrophic muscle, prior to and following gene transfer of therapeutic genes as well as MR marker genes encoding for unique metabolic pathways. Ever since then, I have been using these combined biophysics, MR, and physiology foundations to develop comprehensive ways to monitor and study muscle structure, function, and metabolism in vivo using novel MR and optical imaging techniques. The University of Florida has provided a rich environment to build my research program, with UF being home to the National High Magnetic Field Laboratory (NHMFL), McKnight Brain Institute, Clinical Translational Sciences, Myology, and Powell Gene Therapy Institutes.
I was also a founding member of Southeast Center for Integrated Metabolism, funded through the NIH common fund, and the director of its NMR metabolomics core. I have greater than 20 yrs. of experience with skeletal muscle research, and lead data coordination and analysis cores for multicenter NIH studies focused on the use of MR Imaging/Spectroscopy in preclinical models and in subjects with a range of different types of muscular dystrophy. Specifically, I have extensive experience with MR sequence design, implementation, and processing of MRI/MRS data in neuromuscular diseases on multiple platforms.
Panel Session: The future outlook for medical magnetic resonance imaging superconducting magnets enabled by new materials
New superconducting materials are constantly emerging as the entire world is pushing hard to discover, integrate and scale up superconducting magnet systems for medical magnetic resonance imaging (MRI) machines. These new materials hold the promise of enabling helium-free MRI systems with potentially lower costs to manufacture and operate with increased reliability and resiliency.
The MRI research and development space is a unique field where the intersection of materials science and magnet technology are leveraged in tandem to produce a medical imaging solution that is simply unrivaled by other imaging technologies like X-rays, ultrasound and computerized tomography. Because the imaging quality and utility of MRI is the best amongst all other options, continual improvement in this field has the potential for very significant commercial disruption and economic gains in a rapidly increasing global market.
Moderator: Jeff Whalen
Panelists: Greg Boebinger, Director, MagLab
Ernesto Bosque, MagLab Scientist, Florida State University
Glenn Walter, Professor and Scientist, University of Florida, Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS)
Scott Marshall, Senior Superconducting Magnet Systems Engineer, National High Magnetic Field Laboratory